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Age Related Macular Degeneration

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Research

Researchers at The University of Manchester, UK have been investigating the role of the Macular Pigment and its relation to AMD for many years.  It is suspected that a low level of macular pigment increases the chance of suffering Macular Degeneration in later life therefore some easy method of assessing levels of macular pigment in an individual, and hence their risk, is well worthwhile.
Link to recent publications

Based on their free view Portable Spectral Sensitivity Instrument, FOSSE, ( Perception 19, 359, 1990) they developed a simple technique to assess macular pigment density.

Further research has led to the development of a completely new instrument designed specifically to measure levels of macular pigment in the eye and eliminate the major problems encountered with conventional HFP techniques. For more detailed information have a look at the article in the Optician, Jan 2008. This article not only describes the MPS II basics but shows just how accurate and repeatable the data are. In this case an at risk subject with very low MPOD virtually doubled his levels by taking a supplement.

It is  a compact low cost instrument, which is very easy to use particularly for the patient.  It can be used for serious research and large scale clinical trials as well as more widespread use in Optometric Practice and Pharmaceutical Outlets where it requires minimal operator intervention and many subjects are able to carry out the test totally unaided in only a few minutes. 

In a recent research study Patients, with early stage ARMD in only one eye, together with age-matched none-affected subjects, were given a lutein supplement, which is known to be a vital element in supporting the macular pigment.  The findings indicated that all reacted positively, and macular pigment density increased. Some individuals reacted quickly whilst others seemed to take up to six months before the macular pigment density increased.  

In a recent follow up major study preliminary results show that subjects with early stage ARMD who took a lutein supplement not only showed improvements in their vision but also progression of macular degeneration was significantly slowed.
T
he unit, known in the UK as the MPS II and in the USA as QuantifEYE has been developed to the stage where it can be incorporated, not only into standard optometric eye examinations, but more widespread in, for example, pharmaceutical outlets.  


Developed by researchers at Manchester University and manufactured by Elektron Ophthalmic Instrumentation in the UK is now widely available across the world.

The American company ZeaVision, LLC, has introduced a proprietary program for Eye Care Professionals that can quickly and easily assess risk for Age-Related Macular Degeneration (AMD).QuantifEYE  (Elektron Technology MPS II in the UK) is both CE approved and registered in the USA with the FDA as a Class 1 device and manufactured to the highest standards in the UK.

In the UK the MPS II is available through Elektron Eye Technology and their distrubutors.

The MPS II, (QuantifEYE in the USA)  has been fully validated for measuring Macular Pigment Optical Density and has been compared with other methods of measuring MPOD including the SLO and a macular pigment reflectometer.

This is a completely updated version with improved software which now also provides the user with confidence levels in measured MPOD.  Even more accurate and faster than earlier versions.  (Why not update if you are currently an MPS user).

Recent developments (2017)

Measuring the health of the retina is a vital task in assessing risk for AMD. Researchers at Manchester University, recently funded by the NHS and in association with MuMac Ltd, a new Manchester University spin-out company have developed a completely new method.  This is already patented by the University and promises to revolutionise early detection of AMD risk..

MuMac 'unique' eye tech. could improve 1000s of lives    
Elderly population's eye health to improve following launch of University of Manchester spin-out MuMac.

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